It consists of all the 499 Chinese herbs registered in the Chinese pharmacopoeia with 29,384 ingredients, 3,311 targets and 837 associated diseases. Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski’s rule of five are provided for drug screening and evaluation.
TCMSP also provides drug targets and diseases of each active compound, which can automatically establish the compound-target and target-disease networks that let users view and analyze the drug action mechanisms. It is designed to fuel the development of herbal medicines and to promote integration of modern medicine and traditional medicine for drug discovery and development.
Conclusions: The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature of TCM theory and developing new herb-oriented drugs.
TCMSP is freely available at http://sm.nwsuaf.edu.cn/lsp/tcmsp.php.
Author: Jinlong RuPeng LiJinan WangWei ZhouBohui LiChao HuangPidong LiZihu GuoWeiyang TaoYinfeng YangXue XuYan LiYonghua WangLing Yang
Credits/Source: Journal of Cheminformatics 2014, 6:13
