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   Aug 08

Jiang Tang Xiao Ke Wan fights diabetes mellitus

(foodconsumer.org) — Chinese scientists at Beijing University of Chinese Medicine in Beijing, China published a study in Evidence-Based Complementary and Alternative Medicine suggests that a Chinese herbal medicine called Jiang Tang Xiao Ke Wan is effective at treating type 2 diabetes mellitus.

In the study, rats with antibiotic-induced diabetes mellitus were fed a high fat diet and received the Chinese herbal medicine in a dose of 9 g per kg or pioglitazone in a dose of 1.5 mg per kg for four weeks.

Jiang Tang Xiao Ke Wan used in the study consisted of Radix rehmanniae (Di Huang), Fructus corni (Shan yu rou), Ginseng (Ren Shen), Radix salviae miltiorrhizae (Dan Shen), and Rhizoma coptidis (Huang Lian).

Jiang Tang Xiao Ke Wan lowered serum glucose, total cholesterol, triglyceride, and low density lipoprotein concentrations by 12%, 33%, 57% and 44% respectively while high density lipoprotein cholesterol was increased by 69%, compared with untreated rats with diabetes mellitus.

Additionally, the Chinese herbal medicine also reduced serum malondialdehyde and nitric oxide levels by 34% and 52%, respectively while increasing serum superoxide dismutase levels by 60%.

Jiang Tang Xiao Ke Wan was also found to suppress alanine aminotransferase activity by up to 50% and reduced pathological changes in the pancreas and liver in the diabetes mellitus rats.

Overall, the antidiabetic effect of Jiang Tang Xiao Ke Wan was found to have an antihyperglycemic, antidiabetic effect that is similar to that of Pioglitazone (Actos), a prescription drug with hypoglycemic action to treat diabetes mellitus.

The study concluded that Jiang Tang Xiao Ke Wan may be used as an alternative medicine for the management of diabetes mellitus. (David Liu, PHD)

Zhao DD, Yu N, Li XK, Fang X, Mu QQ, Qin PJ, Ma Y, Mo FF, Zhang DW, Gao SH. Antidiabetic and antioxidative effect of jiang tang xiao ke granule in high-fat diet and low-dose streptozotocin induced diabetic rats. Evid Based Complement Alternat Med. 2014;2014:475192.


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