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   Apr 04

Are you ‘resistant’ to exercise? Researchers reveal why working out has no health benefits for some

Exercise affects individuals differently and some derive little benefit

It’s all down to a protein that’s secreted in the liver, say researchers

Findings may lead to exercise-enhancing drugs, experts believe
Some people experience greater rewards from exercise than others.

New research may have shed light on why this is – a liver protein may be to blame for ‘exercise resistance’.

According to experts in Japan, ‘some people derive little benefit from the health-promoting effects of regular exercise’.

In a study involving both mice and humans, higher levels of selenoprotein P – a protein secreted by the liver – was found to be linked with reduced exercise capacity and fewer exercise-related benefits.

New research suggests that a liver protein may be to blame for exercise resistance

The findings, from Kanazawa University, could mean selenoprotein P may be a driver of low responsiveness to exercise, or ‘exercise resistance’ as the scientists label it.

To test their theory, the researchers carried out two studies. The first was on a group of mice who were subjected to 30 minute treadmill runs for one month.

At the end of the month, the selenoprotein P-deficient mice showed higher exercise capacity than regular lab mice.

Additionally, the researchers found that mice lacking LRP1 – a selenoprotein P receptor in muscles – were unable to absorb selenoprotein P into their muscles.

The second study involved 31 healthy but sedentary women who underwent aerobic training for eight weeks.

Scientists measured their maximal oxygen consumption and found that those who had high level of selenoprotein P in the blood before training did not show much elevation.

When maximal oxygen consumption is elevated, the body can take in more oxygen and deliver it to the muscles, enabling faster running.

The research could shed light on diseases resulting from a sedentary lifestyle such as obesity and type-2 diabetes.

NHS guidelines say adults aged 19-64 should do at least 150 minutes of moderate aerobic activity such as cycling or fast walking every week, and strength exercises on two or more days a week

The study’s authors note: ‘In particular, some people show complete non-responsiveness to exercise training in terms of aerobic improvement.

‘Similarly, 15-20 percent of patients with type 2 diabetes show a poor hypoglycemic effect to regular exercise therapy.

‘These findings indicate that some people suffer from exercise resistance and derive limited benefits from the health-promoting effects of physical exercise.’

The team believes that the research findings may pave the way for drugs that reduce selenoprotein P production to improve exercise endurance.

Study co-author Hirofumi Misu and colleagues write: ‘The current findings suggest that future screening for inhibitors of the [selenoprotein P]-LRP1 axis could identify exercise-enhancing drugs to treat physical-inactivity-associated diseases such as type 2 diabetes.’

The study was published in the journal Nature Medicine.

Source: Daily Mail

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