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   Apr 08

Exploratory clinical trial to evaluate the efficacy of a topical traditional CHM in psoriasis vulgaris.

Yan Y, Liu W, Andres P, Pernin C, Chantalat L, Briantais P, Lin A, Feng L. Evid Based Complement Alternat Med. 2015;2015:719641. doi: 10.1155/2015/719641. Epub 2015 Mar 5.

OBJECTIVE: To evaluate the efficacy and safety of herbal ointment, Shidu Ruangao, in patients with plaque-type psoriasis. DESIGN: Single-center, randomized, investigator-blinded, parallel group, placebo-controlled study.

PARTICIPANTS: 100 outpatients with mild to moderate chronic plaque-type psoriasis were enrolled.

INTERVENTION: The patients applied either Shidu Ruangao ointment or vehicle ointment topically to for 8 weeks.

MAIN OUTCOME MEASURES: The outcomes were assessed using the following criteria: Total Severity Score (TSS, sum of erythema, scaling, and plaque elevation/induration, on 0-4 scale), Investiagator Global Assessment (IGA) evaluated on a 0 (Clear) to 4 (severe to very severe) scale, and Global Subjects’ Assessment of treatment response on a 7-point scale from -1 (worse) to 5 (Cleared).

RESULTS: Significant reductions in the Total Severity Score (p<.001) (mean score: 2.7 after Shidu Ruangao treatment versus 5.1 in control subjects). Both Investigator Global Assessment (IGA) and Global Subjects’ Assessment of treatment are better in the Shidu Ruangao group than the control group (p<.001).

CONCLUSION: Shidu Ruangao ointment was a safe, and effective therapy for plaque-type psoriasis. PMID: 25834623 [PubMed]

Phil: SHIDU RUANGAO contained Qingdai, Huangbai, Duanshigao, Luganshi and Wubeizi. See full-text at http://www.hindawi.com/journals/ecam/2015/719641/

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